Extracellular vesicles (EVs) are composed of a lipid bilayer containing transmembrane and soluble proteins.Subtypes of EVs include ectosomes (microparticles/microvesicles), exosomes, and apoptotic bodies that can be released by various tissues into biological fluids.EV cargo can modulate physiological and pathological processes in recipient cells t
At the culmination of poliovirus (PV) multiplication, membranes are observed that contain phosphatidylinositol-4-phosphate (PI4P) and appear as vesicular clusters in cross section.Induction and remodeling of PI4P and membranes prior to or concurrent with genome replication has not been well studied.Here, we exploit two PV mutants, termed EG and GG,
Blockchain technology has brought a significant advancement in the development of academic certificate management systems by enhancing security, transparency, and decentralization.However, challenges such as certificate revocation, transaction costs, and latency still persist.This research proposes a novel mechanism combining smart contracts and Op
Apicomplexa are obligate intracellular pathogens that have fine-tuned their proliferative strategies to match a large variety of host cells.A critical aspect of this adaptation is a flexible cell cycle that remains poorly understood at the mechanistic level.Here we describe a forward genetic dissection of the apicomplexan cell cycle using the Toxop
The title molecule, C21H25NO7, has four stereogenic centres and crystallized as a racemate.It consists of First Aid Kits enantiomeric pairs with the relative configuration rac-(1R*,2S*,3R*).The cyclohexenone ring adopts an envelope conformation; the dimethyl-substituted C atom lies 0.640 (1) Å out of the mean plane formed by the re